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Brucellosis is characterized by a tendency to a chronic course, which is associated with a long stay of brucella in the body.

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Chronic forms are characterized by a syndrome of general intoxication (weakness, headache). Common symptoms include prolonged low temperature, weakness, increased irritability, poor sleep, impaired appetite, decreased performance. Almost all patients have an increase in lymph nodes. The liver and spleen are often enlarged. Against this background, lesions of the joints, nervous and reproductive systems are noted. With brucellosis, there may be other lesions (pneumonia, myocarditis, eye lesions, etc.), but they are less common.

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The defeat of the musculoskeletal system is the most common manifestation of chronic brucellosis. Patients complain of pain in muscles and joints, mainly in large ones. The knee and elbow are most commonly affectedeve, shoulder, hip joints, rarely - small joints of the hand and feet. The joints swell, their mobility is limited, and the skin over them is usually normal in color. Impaired mobility and deformity of the joints are caused by the growth of bone tissue. The spine is affected, more often in the lumbar region.

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Sometimes there are changes in the eyes (iritis, chorioretinitis, uveitis, keratitis, optic nerve atrophy, etc.). With aerogenic infection, sluggish brucellosis pneumonia often develops, which are unsuccessfully treated with antibiotics. There may be myocarditis, endocarditis, aortitis and other lesions of combivent inhaler. The principles and methods of treatment depend on the form of brucellosis.

Antibiotic therapy can give an effect only in the acute (acute) form of brucellosis, in chronic forms, the appointment of antibiotics plays an auxiliary role, vaccine therapy is of primary importance.

With this form, it is necessary to prescribe antibiotics in fairly large doses. Insufficient doses and premature withdrawal of drugs cause the development of a chronic form of brucellosis in the future. Antibiotics must be given continuously. Tetracycline - 0.5 g every 6 hours for 3-6 weeks, during the first 2 weeks, in addition, streptomycin was used (intramuscularly) at a dose of 1 g every 12 hours. Tetracycline is contraindicated in pregnant women and children under 8 years of age.

If it is impossible to use the above scheme, you can prescribe biseptol (co-trimoxazole) 6 tablets per day for 4 weeks. The combination of ipratropium online rifampicin (900 mg per day) gives the best results. When conducting a full course, relapses are rare. Vitamins are prescribed. 

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Treatment of acute form of brucellosis.

For treatment, a dose is selected that causes a moderate reaction. The next injection of the vaccine is done only after the reaction to the previous injection of the vaccine has disappeared. A single dose at the end of the course is adjusted to 1-5 billion microbial cells.

Intradermal vaccine therapy is more gentle. This method is used in the stage of compensation, as well as during the transition of Generic Combivent (Levosalbutamol / Ipratropium bromide) into a latent form. According to the severity of the skin reaction, a working dilution of the vaccine is selected (it should cause a local reaction in the form of reddening of the skin with a diameter of 5 to 10 mm). The vaccine is injected intradermally into the palmar surface of the forearm on the first day, 0.1 ml in 3 places, then 1 injection is added every day and brought up to 10 injections on the 8th day. If the response to the vaccine decreases, to take a more concentrated dilution.

It should be borne in mind that even with the complete disappearance of all clinical manifestations, 20-30% may experience an exacerbation of the disease in the future. The prognosis for life with brucellosis is favorable.

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The greatest distribution in the treatment of ipratropium 50/20mcg brucellosis received subcutaneous and intradermal administration of the vaccine. Subcutaneously, the vaccine is prescribed for worsening of the course of brucellosis and with a pronounced process. An important principle of vaccine therapy is the individual selection of the dose of the drug. To some extent, the severity of the reaction is judged by the intensity of the Burne test. Subcutaneous administration often begins with 10-50 million microbial cells. If there are no local and general reactions, then the vaccine in an increased dose is administered the very next day.

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The live vaccine is prescribed only for preventive purposes. Various methods of vaccine administration have been proposed. intravenous, intramuscular, subcutaneous and intradermal. It must be remembered that an inaccurate dosage of combivent can lead to an exacerbation of the disease (with an overdose) or to the absence of a pronounced effect (with an insufficient dose). In this regard, the choice of the method of administration and the calculation of the individual dose plays an important role.

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With a pronounced allergic restructuring, brucellin is used, but most often a special (killed) therapeutic vaccine.

Patients are prescribed a complex of vitamins, non-specific stimulants of hematopoiesis (pentoxyl, sodium nucleic acid, metacil). In winter, it is necessary to carry out general ultraviolet irradiation. Apply antihistamines (pipolfen, suprastin, etc.). With severe inflammatory changes (orchitis, neuritis, etc.), corticosteroid drugs are prescribed (40-50 mg of prednisolone for 2-3 weeks or comparable doses of other corticosteroids). Vaccine therapy is used for specific desensitization and immunity enhancement.

Treatment of the chronic form. Antibiotics in chronic forms of brucellosis were ineffective. The main role in these forms is played by the appointment of combivent drugs with nonspecific and specific desensitizing effects. In chronic forms, vaccine therapy is most effective, which is not only a desensitizing measure, but also stimulates the immune system.